A federal government Website managed by the National Vaccine Program Office,
U.S. Department of Health and Human Services (HHS)
Every year, thousands of people around the world die from rabies. Rabies is a rare disease in the United States, but it’s almost always deadly. The good news is that this disease is preventable with the rabies vaccine.
The rabies vaccine is given to people who are at higher risk of coming in contact with rabies — like veterinarians. It’s also given to people after an animal bite if the animal could have rabies.
If you’re bitten by an animal that could have rabies, contact your doctor right away. Learn more about seeking medical attention for rabies.
Though it’s rare in the United States, people who get rabies almost always die. In the United States people are most likely to get rabies from wild animals. Rabies is more common in other countries.
If you’ve been bitten by an animal that could have rabies, or are at risk of coming in contact with rabies, it’s very important to get the vaccine.
Rabies is caused by a virus that can be passed to humans through the bite of a rabid animal (an animal who has it). People in the United States are most likely to get rabies from wild animals, especially bats. Animals like raccoons, skunks, and foxes may also spread rabies. It’s also possible to get rabies from pets, like dogs and cats, that haven’t been vaccinated. In countries where rabies is still common, people often get it through the bite of a rabid dog.
Rabies doesn’t generally spread from person to person — though very rarely, it could spread from one person to another during an organ transplant.
Early symptoms of rabies include:
As the disease gets worse, rabies can cause:
- Trouble sleeping
- Feeling confused
- Anxiety and agitation (feeling nervous, worried, or upset)
- Seizures (sudden, unusal movements or behavior)
- Hallucinations (seeing things that aren’t there)
Once a person shows symptoms of rabies, they almost always die. Learn more about rabies.
People at risk of rabies
The rabies vaccine is recommended for people at high risk of coming in contact with rabies. For example, you may need the rabies vaccine if you:
- Work as a veterinarian or animal handler
- Study or explore caves
- Study the rabies virus
- Are traveling to other countries where rabies is common
The vaccine is given in 3 doses. The second dose is given 7 days after the first dose, followed by a third dose 21 or 28 days after the first.
Vaccination after an animal bite
If you’re bitten by an animal that could have rabies, you can get the rabies vaccine to keep you from developing the disease. A doctor can help decide if you need the vaccine.
If you haven’t been vaccinated for rabies before, you’ll need 4 doses of the vaccine. You’ll get the first dose right away, followed by additional doses:
- 3 days after the first dose
- 1 week after the first dose
- 2 weeks after the first dose
People who have a weakened immune system need another dose 4 weeks after the first dose.
You’ll also get a shot called Rabies Immune Globulin with the first dose to help your body fight the virus faster.
If you’ve already had the rabies vaccine, you’ll need 2 doses after an animal bite — you’ll get the first dose right away, followed by a second dose 3 days after the first. You won’t need the Rabies Immune Globulin shot.
If you think you or someone in your family needs the rabies vaccine, talk with a doctor.
Some people should not get the rabies vaccine — or may need to wait to get it. Be sure to tell your doctor before getting vaccinated if you:
- Have had an allergic reaction to the rabies vaccine in the past
- Have other severe allergies
- Have HIV/AIDS
- Have cancer
- Are taking medicines that can affect your immune system
If you’ve already come in contact with rabies — like if you’ve been bitten by an animal that could have rabies — you’ll need to get the vaccine even if you have any of these conditions.
Side effects are usually mild and go away in a few days. They may include:
- Pain, swelling, or redness where the shot was given
- Upset stomach
- Stomach pain
- Muscles aches
Less common side effects of the rabies vaccine include:
- Hives (itchy spots on the skin)
- Joint pain
Serious side effects from the rabies vaccine are very rare.
Like any medicine, there's a very small chance that the rabies vaccine could cause a serious reaction. Keep in mind that getting the rabies vaccine is much safer than getting rabies. Learn more about vaccine side effects.
Vaccine Information Statements (VISs) have detailed information about recommended vaccines.
Last reviewed: January 2018