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Japanese Encephalitis (JE)

Vaccines to Prevent Japanese Encephalitis

Vaccine Basics

For Children and Adolescents

JE-VAX, the only Japanese Encephalitis (JE) vaccine licensed for use in children in the United States, is no longer available. JE-VAX is no longer being produced and all remaining doses expired in May 2011. 

Other JE vaccines are manufactured and available for pediatric use in Asia but are not licensed in the United States. Despite ongoing studies, it will likely be several years before a JE vaccine is licensed in the United States for use in children.

For more information, visit the CDC website to read “Update on Japanese Encephalitis (JE) Vaccine for U.S. Children.”



For Adults

Ixiaro is given only to people 17 years of age and older. 

  • The vaccine is given as a two-dose series, with the doses spaced 28 days apart.
  • The last dose should be given at least one week before travel.
  • If you can’t complete this series before you travel, ask your provider about alternatives.
  • The need for and timing of booster doses is not known at this time.
  • Ixiaro vaccine may be given at the same time as other vaccines.
Learn About JE

What is Japanese Encephalitis (JE)?

Japanese encephalitis (JE) is a serious infection caused by a virus. It occurs mainly in rural parts of Asia.

JE virus spreads through the bite of infected mosquitoes. It cannot spread directly from person to person. The risk of JE is very low for most travelers, but it is higher for people living or traveling for long periods in areas where the disease is common.

Most people infected with JE virus don’t have any symptoms at all. For others, JE virus infection can cause illness ranging from fever and headache to severe encephalitis (brain infection).

Symptoms of encephalitis are fever, neck stiffness, seizures, changes in consciousness, or coma.

About one person in four with encephalitis dies. Of those who don’t die, up to half may suffer permanent brain damage. There is some evidence that an infection in a pregnant woman can harm her unborn baby.

Who gets Japanese Encephalitis (JE)?

Residents of rural areas in endemic locations, active duty military deployed to endemic areas, and visitors to these rural areas are at higher risk for Japanese Encephalitis (JE). Japanese encephalitis does not usually occur in urban areas.

Travelers to parts of Asia are at higher risk for JE, and should ask their providers about vaccination before traveling.

Take Action

Ready to get vaccinated?


Learn more about the vaccine recommendations for you.


Read more about the Japanese Encephalitis vaccine:

Going to get vaccinated:


  • Japanese Encephalitis (JE) is more common in some countries than others. Find out if you should be vaccinated before you travel abroad.